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Protective clothing plays a vital role in safety and security. Traditional protective clothing can protect the human body from physical injury. [https://www.selleckchem.com/products/Nicotinamide(Niacinamide).html Niacinamide datasheet] It is highly desirable to integrate modern wearable electronics into a traditional protection suit to endow it with versatile smart functions. However, it is still challenging to integrate electronics into clothing through a practical approach while keeping the intrinsic flexibility and breathability of textiles. In this work, we realized the direct writing of laser-induced graphene (LIG) on a Kevlar textile in air and demonstrated the applications of the as-prepared Janus graphene/Kevlar textile in intelligent protective clothing. The C═O and N-C bonds in Kevlar were broken, and the remaining carbon atoms were reorganized into graphene, which can be ascribed to a photothermal effect induced by the laser irradiation. Proof-of-concept devices based on the prepared graphene/Kevlar textile, including flexible Zn-air batteries, electrocardiogram electrodes, and NO2 sensors, were demonstrated. link2 Further, we fabricated self-powered and intelligent protective clothing based on the graphene/Kevlar textile. The laser-induced direct writing of graphene from commercial textiles in air conditions provides a versatile and rapid route for the fabrication of textile electronics.In this study, a simple microfluidic method, which can be universally applied to different rigid or flexible substrates, was developed to fabricate high-resolution, conductive, two-dimensional and three-dimensional microstructured graphene-based electronic circuits. The method involves controlled and selective filling of microchannels on substrate surfaces with a conductive binder-free graphene nanoplatelet (GNP) solution. The ethanol-thermal reaction of GNP solution at low temperatures (∼75 °C) prior to microchannel filling (preheating) can further reduce the GNP andprovide a homogeneous GNP solution, which in turn enhances conductivity, reduces sheet resistance (∼0.05 kΩ sq-1), enables room-temperature fabrication, and eliminates harsh postprocessing, which makes this fabrication technique compatible with degradable substrates. This method can also be used in combination with 3D printing to fabricate 3D circuits. The feature sizes of the graphene patterns can range from a few micrometers (down to ∼15 μm in width and ∼5 μm in depth) to a few millimeters and use very small amounts of GNP solution (∼2.5 mg of graphene to obtain ∼0.1 kΩ sq-1 of sheet resistance for 1 cm2). This microfluidic approach can also be implemented using other conductive liquids, such as conductive graphene-silver solutions. This technology has the potential to pave the way for low-cost, disposable, and biodegradable circuits for a range of electronic applications including near-field communication antennas and pressure or strain sensors.Adenosine is important for local neuromodulation, and rapid adenosine signaling can occur spontaneously or after mechanical stimulation, but little is known about how adenosine is formed in the extracellular space for those stimulations. Here, we studied mechanically stimulated and spontaneous adenosine to determine if rapid adenosine is formed by extracellular breakdown of adenosine triphosphate (ATP) using mice globally deficient in extracellular breakdown enzymes, either CD39 (nucleoside triphosphate diphosphohydrolase 1, NTPDase1) or CD73 (ecto-5'-nucleotidase). CD39 knockout (KO) mice have a lower frequency of spontaneous adenosine events than wild-type (WT, C57BL/6). Surprisingly, CD73KO mice demonstrate sex differences in spontaneous adenosine; males maintain similar event frequencies as WT, but females have significantly fewer events and lower concentrations. Examining the mRNA expression of other enzymes that metabolize ATP revealed tissue nonspecific alkaline phosphatase (TNAP) was upregulated in male CD73KO mice, but not secreted prostatic acid phosphatase (PAP) or transmembrane PAP. Thus, TNAP upregulation compensates for CD73 loss in males but not in females. These sex differences highlight that spontaneous adenosine is formed by metabolism of extracellular ATP by many enzymes. For mechanically stimulated adenosine, CD39KO or CD73KO did not change stimulation frequency, concentration, or t1/2. Thus, the mechanism of formation for mechanically stimulated adenosine is likely direct release of adenosine, different than spontaneous adenosine. Understanding these different mechanisms of rapid adenosine formation will help to develop pharmacological treatments that differentially target modes of rapid adenosine signaling, and all treatments should be studied in both sexes, given possible differences in extracellular ATP degradation.The volume variation of electrode materials will lead to poor cyclability of lithium-ion batteries during the lithiation/delithiation process. link3 Instead, inner-stress fragmentation is creatively used to change carbon-layer-capped Fe3O4 particles ∼30 nm in diameter into high-density Fe3O4 dots ∼4 nm in size embedded in ultrathin carbon layers. The optimized structure shows a remarkable 45.2% enhancement of lithium storage from 804.7 (the 10th cycle) to 1168.7 mA h g-1 (the 250th cycle) at 500 mA g-1, even retaining 1239.5 mA h g-1 after another 550 cycles. The electrochemical measurements reveal the enhanced capacitive behavior of the high-density Fe3O4 dots@C layers, which have more extra active sites for the insertion/extraction of Li+ ions, confirmed by the differential capacity plots, leading to remarkably increased specific capacity during cycling. The restructured electrode also shows a superior rate capacity and excellent cycling stability (938.7 and 815.4 mA h g-1 over 2000 cycles at 1000 and 2000 mA g-1, respectively). X-ray photoelectron spectroscopy and transmission electron microscopy characterizations show that the optimized structure has stable structural and componential stability even at large rates. This work presents an MOF-guided synthesis of high-density Fe3O4-dots' anode material optimized by inner-stress fragmentation, showing a feasible route to design high-efficiency electrode materials.Solar-driven water evaporation has been proposed as a renewable and sustainable strategy for the generation of clean water from seawater or wastewater. To enable such technologies, development of photothermal materials that enable efficient solar steam generation is essential. The current challenge is to manufacture such photothermal materials cost-effectively and at scale. Furthermore, the photothermal materials should be strongly hydrophilic and environmentally stable. Herein, we demonstrate facile and scalable fabrication of carbon nanotube (CNT)-based photothermal nanocomposite foam by igniting an ethanol solution of ferric acetylacetonate [Fe(acac)3] absorbed within nickel (Ni) foam under ambient conditions. The Fe(acac)3 precursor provides carbon and the zero-valent iron catalyst for growing CNTs on the Ni foam, while ethanol facilitates the dispersion of Fe(acac)3 on the Ni foam and supplies heat energy for the growth of CNTs by its burning. A forest of dense and uniform CNTs decorated with Fe2O3 nanoparticles is generated within seconds. The resultant Fe2O3/CNT/Ni nanocomposite foam exhibits "superhydrophilicity" and high light absorption capacity, ensuring rapid transport and fast evaporation of water within the entire foam. Efficient light-to-heat conversion causes the surface temperature of the foam to reach ∼83.1 °C under 1 sun irradiation. The average water evaporation rates of such foam are as high as ∼1.48 and ∼4.27 kg m-2 h-1 with light-to-heat conversion efficiencies of ∼81.3 and ∼93.8% under 1 sun and 3 sun irradiation, respectively. Moreover, the versatile and scalable combustion synthesis strategy presented here can be realized on various substrates, exhibiting high adaptability for different applications.As genome mining becomes a more widely used approach to identify bacterial natural products, the challenge of matching biosynthetic gene clusters to their cognate secondary metabolites has become more apparent. Bioinformatic platforms such as AntiSMASH have made great progress in predicting chemical structures from genetic information, however the predicted structures are often incomplete. This complicates identifying the predicted compounds by mass spectrometry. Secondary metabolites produced by cyanobacteria represent a unique opportunity for bridging this gap. Cultured cyanobacteria incorporate inorganic nitrogen provided in chemically defined media into all nitrogen-containing secondary metabolites. Thus, stable isotope labeling with 15N labeled nitrate and subsequent comparative metabolomics can be used to match biosynthetic gene clusters to their cognate compounds in cell extracts. Analysis of the sequenced genome of Nostoc sp. UIC 10630 identified six biosynthetic gene clusters predicted to encode the production of a secondary metabolite with at least one nitrogen atom. Comparative metabolomic analysis of the 15N labeled and unlabeled cell extracts revealed four nitrogen containing compounds that contained the same number of nitrogen atoms as were predicted in the biosynthetic gene clusters. Two of the four compounds were new secondary metabolites, and their structures were elucidated by NMR, HRESIMS, and MS/MS.Silencing the inhibitor of apoptosis (IAP) by RNAi is a promising method for tumor therapy. One of the major challenges lies in how to sequentially overcome the system barriers in the course of the tumor targeting delivery, especially in the tumor accumulation and penetration. Herein we developed a novel stimuli-responsive polysaccharide enveloped liposome carrier, which was constructed by layer-by-layer depositing redox-sensitive amphiphilic chitosan (CS) and hyaluronic acid (HA) onto the liposome and then loading IAP inhibitor survivin-shRNA gene and permeation promoter hyaluronidase (HAase) sequentially. The as-prepared HA/HAase/CS/liposome/shRNA (HCLR) nanocarrier was verified to be stable in blood circulation due to the negative charged HA shield. The tumor targeting recognition and the enhanced tumor accumulation of HCLR were visualized by fluorescence resonance energy transfer (FRET) and in vivo fluorescence biodistribution. The deshielding of HA and the protonizing of CS in slightly acidic tumor extracellular pH environment (pHe, 6.8~6.5) were demonstrated by zeta potential change from -23.1 mV to 29.9 mV. The pHe responsive HAase release was confirmed in the tumor extracellular mimicking environments, and the intratumoral biodistribution showed that the tumor penetration of HCLR was improved. The cell uptake of HCLR in pHe environment was significantly enhanced compared with that in physiological pH environment. The increased shRNA release of HCLR was approved in 10 mM glutathione (GSH) and tumor cells. Surprisingly, HCLR suppressed the tumor growth markedly through survivin silencing and meanwhile maintained low toxicity to mice. This study indicates that the novel polysaccharide enveloped HCLR is promising in clinical translation, thanks to the stimuli-triggered tumor accumulation, tumor penetration, cell uptake and intracellular gene release.