Zobrazení zdroje stránky Bertramgravesen9125

BACKGROUND Activity trackers are becoming increasingly popular, but patients often hesitate to share the data from such devices with their health care providers. Researchers have shown that sharing everyday health data with physicians can foster greater patient engagement. OBJECTIVES This research is intended to investigate activity tracker users' decisions regarding the sharing of their activity tracker data with physicians, as well as to build a stage based framework for improving patient engagement by fostering such data sharing. METHODS Qualitative analysis of interview records of 12 adults, who had used Fitbit activity tracking devices for up to two years, identifying emotions and experiences surrounding their tendencies to share physical exercise data with a physician. RESULTS This research used the subjects' emotions and considerations regarding the decision over whether to share exercise data with physicians to create a stage based framework with three stages cognisance, tangible evidence and supportive feedback. CONCLUSION The tendency to progress towards three stages with greater patient-physician engagement appears to increase with health risk profile and with reduced data privacy concerns. This framework contributes to ongoing discussions about establishing patient-practitioner engagement, based around patients' shared personal data collection. © 2020 Health Libraries Group.AIM We report clinical outcomes of transarterial embolization in 19 cases of vaginal cancer. METHODS From August 2011 to October 2019, 19 patients with histologically diagnosed vaginal cancer were identified in our department. Transarterial chemotherapy and embolization was performed for all patients. Patient characteristics, treatment plans and the clinical outcomes, were recorded. RESULTS Among 19 identified cases, nine of them are squamous cell carcinoma, five of adenocarcinoma, one of adenosquamous carcinoma, two of vaginal malignant melanoma, one leiomyosarcoma and one of stromal sarcoma. Transarterial chemotherapy and embolization was successfully performed in all patients. No related complication was found after intervention treatment. Besides, eight patients received adjuvant chemotherapy, four received both adjuvant chemotherapy and radiotherapy and seven received no therapies. Four patients were cured and seven were stable during follow-up. CONCLUSION Transarterial embolization appears safe and effective for vaginal cancer, with a currently acceptable prognosis. © 2020 Japan Society of Obstetrics and Gynecology.INTRODUCTION Stigma and disclosure concerns have been key barriers to oral pre-exposure prophylaxis (PrEP) adherence for African adolescent girls and young women (AGYW) in efficacy trials. We aimed to understand the impact of these factors among African AGYW in an open-label PrEP study. METHODS HPTN 082 was an open-label PrEP study among AGYW (ages 16 to 24) in Harare, Zimbabwe, and Cape Town and Johannesburg, South Africa from 2016 to 2018. Women starting PrEP were randomized to standard adherence support (counselling, two-way SMS, monthly adherence clubs) or standard support plus drug-level feedback. Serial in-depth interviews were conducted among 67 AGYW after 13-week and 26-week study visits to explore experiences of stigma, disclosure and PrEP adherence. We analysed data by coding transcripts and memo-writing and diagramming to summarize themes. RESULTS AGYW described stigma related to sexual activity (e.g. [https://www.selleckchem.com/products/ws6.html WS6 supplier] "people say I'm a prostitute") and being perceived to be living with HIV because of taking antiretrEP use over their first six months of PrEP use, which helped them cope with stigma and feel more able to take PrEP regularly. PrEP programmes can foster disclosure through community and clinic-based discussion, adherence clubs and activities normalizing sexual behaviour and PrEP use, which can reduce stigma and improve PrEP adherence and thus effectiveness. © 2020 The Authors. Journal of the International AIDS Society published by John Wiley &amp; Sons Ltd on behalf of the International AIDS Society.Recruitment obstacles with Spanish-speaking individuals and members of marginalized communities have been documented in the literature in narrative form, but quantitative data on effective strategies are limited. Within our research protocol assessing the impact of a storytelling intervention on knowledge and uptake of cell-free DNA (cfDNA) aneuploidy screening, three different recruitment strategies were trialed and enrollment rates were compared. Throughout the study, field notes were collected from observations in recruitment efforts. We demonstrate the effectiveness of language-concordant, personal interactions, and culturally tailored materials for recruitment of Spanish-speaking participants into genomic research studies. We also offer commentary on the experience of the researchers that provides insights to inform recruitment methods for marginalized communities. © 2020 National Society of Genetic Counselors.AIMS The body responds to exercise training by profound adaptations throughout the cardiorespiratory and muscular systems, which may result in improvements in maximal oxygen consumption (VO2 peak) and mitochondrial capacity. By convenience, mitochondrial respiration is often measured at supra-physiological oxygen levels, an approach that ignores any potential regulatory role of mitochondrial affinity for oxygen (p50mito ) at physiological oxygen levels. METHODS In this study, we examined the p50mito of mitochondria isolated from the Vastus lateralis and Triceps brachii in 12 healthy volunteers before and after a training intervention with seven sessions of sprint interval training using both leg cycling and arm cranking. The changes in p50mito were compared to changes in whole-body VO2 peak. RESULTS We here show that p50mito is similar in isolated mitochondria from the Vastus (40&nbsp;±&nbsp;3.8&nbsp;Pa) compared to Triceps (39&nbsp;±&nbsp;3.3) but decreases (mitochondrial oxygen affinity increases) after seven sessions of sprint interval training (to 26&nbsp;±&nbsp;2.2&nbsp;Pa in Vastus and 22&nbsp;±&nbsp;2.7&nbsp;Pa in Triceps, both P&nbsp; less then &nbsp;.01). The change in VO2 peak modelled from changes in p50mito was correlated to actual measured changes in VO2 peak (R2 &nbsp;=&nbsp;.41, P&nbsp;=&nbsp;.002). CONCLUSION Together with mitochondrial respiratory capacity, p50mito is a critical factor when measuring mitochondrial function, it can decrease with sprint interval training and should be considered in the integrative analysis of the oxygen cascade from lung to mitochondria. © 2020 The Authors. Acta Physiologica published by John Wiley &amp; Sons Ltd on behalf of Scandinavian Physiological Society.