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78; 95% confidence interval, 1.05-3.03; P&nbsp;= .015) and&nbsp;≥ 3 metastatic sites (hazard ratio, 3.97; 95% confidence interval, 1.97-8.01; P&nbsp; less then .001) were independently correlated with poor PFS. Patients with irAE and patients without interstitial lung disease had significantly longer PFS (14.0 and 4.9 months, respectively; P&nbsp;= .011) than patients without irAE or patients with interstitial lung disease. CONCLUSION The outcome of patients receiving first-line pembrolizumab treatment was worse in those with nonadenocarcinoma and with a large number of metastatic sites. Patients with irAE and without interstitial lung disease had a more favorable outcome. PURPOSE The association between periodontal disease and carotid atherosclerosis has been widely discussed, but to our knowledge, no population-based studies have been conducted on the association between masticatory ability and carotid atherosclerosis. We aimed to clarify the hypothesis that objectively accessed masticatory performance is related to increased intima-media thickness (IMT) in a general urban population. METHODS We studied 1,484 Japanese (mean age 66.9 y) from the Suita study. Masticatory performance was measured using test gummy jelly, and periodontal status was evaluated using the Community Periodontal Index (CPI). Carotid ultrasonography was performed to measure maximum IMT (max-IMT) in the entire area of the carotid arteries. Analysis of covariance was used to compare max-IMT according to quartiles of masticatory performance adjusted by cardiovascular risk factors and periodontal status. RESULTS Multivariable-adjusted max-IMT (standard error) was significantly higher in the lowest masticatory performance quartile group (decreased group) (1.58&nbsp;±&nbsp;0.03 and 1.44&nbsp;±&nbsp;0.03 mm) than in the 2nd to 4th quartiles combined (non-decreased groups) in both sexes (1.48&nbsp;±&nbsp;0.02 mm, trend P = 0.038) and in women (1.34&nbsp;±&nbsp;0.02 mm, trend P = 0.013), respectively. In participants without cardiovascular risk factors (n = 250), multivariable-adjusted max-IMT was significantly higher in the decreased (1.54&nbsp;±&nbsp;0.06, 2.08&nbsp;±&nbsp;0.22, and 1.42&nbsp;±&nbsp;0.06 mm) than in the non-decreased groups in both sexes (1.31&nbsp;±&nbsp;0.04 mm, trend P = 0.006), in men (1.41&nbsp;±&nbsp;0.12 mm, trend P = 0.028), and in women (1.28&nbsp;±&nbsp;0.04 mm, trend P = 0.073). CONCLUSIONS These findings suggest that decreased masticatory performance may be related to carotid IMT progression in the general urban Japanese population. [https://www.selleckchem.com/products/BafilomycinA1.html learn more] INTRODUCTION Radiographers have a duty to ensure that radiation doses to patients are as low as reasonably achievable. With digital technologies, exposure factors which achieve the optimum balance between image noise and patient dose must be sought. In digital radiography, Deviation Index (DI) values provide the radiographer with feedback on the appropriateness of individual exposures but can also be tracked as part of a departmental quality assurance programme. METHODS In November 2017, exposure logs were extracted from six digital radiography (DR) x-ray systems, collated and analysed. Five examinations were identified which frequently produced DI values outside the manufacturer's recommended Optimal Range (-3 to&nbsp;+2). Incremental improvements were made to the default exposure settings for these examinations via a cyclical process of modification and re-evaluation. A full data collection exercise was then repeated in April 2019. RESULTS At baseline, 10,658 out of 29,637 (36.0%) exposures had DI values outside the manufacturer's recommended Optimal Range, but for some individual examinations the proportion was as high as 547 out of 725 (74.5%). Following multiple optimisation cycles, the overall proportion of examinations outside the Optimal Range had fallen to 7611 out of 26,759 (28.4%). Default milliampere-seconds (mAs) values for these examinations were reduced by between 22% and 50%. CONCLUSION A marked reduction in patient doses can be achieved through a departmental programme of DI value monitoring and targeted optimisation of default exposure settings. IMPLICATIONS FOR PRACTICE DI values should be routinely monitored as part of routine quality assurance programmes. Radiographers have a responsibility to ensure that they possess a clear understanding of DI values and that appropriate exposure settings are selected for each individual patient. OBJECTIVE The aim of this study was to evaluate the safety and clinical outcomes of percutaneous sclerotherapy of venous disorders of the labia majora in patients with vascular malformations of the lower limbs. METHODS Thirty percutaneous sclerotherapy treatments were performed over a 6-year period among 17 female patients with symptomatic venous malformation (VM) or secondary varicosis of the labia majora. Four patients were treated with sclerotherapy alone, 13 patients had additional procedures to control the VM before sclerotherapy. Polidocanol was used as sclerosant. Indications for sclerotherapy included pain, bleeding, thrombophlebitis, and swelling. Genitourinary symptoms were recorded. The number of treatments and procedure-related complications were registered. Complications were classified according to the Society of Interventional Radiology (SIR) classification system (grade A-E). The 3-month postintervention follow-up included magnetic resonance imaging, clinical examination, and a symptom-related questionnaire. If no reintervention was necessary, consultation was scheduled biannually. RESULTS All patients had local swelling and pain; only a fraction of the patients had further symptoms with bleeding or thrombophlebitis (47% each). Eight patients required reintervention. No major complications were observed; minor complications such as postprocedural swelling occurred in 29% (SIR grade A), pain occurred in 17% (SIR grade B), and skin blistering developed in 5% (SIR grade B). Upon follow-up examination after a median of 40&nbsp;months, 76% showed complete relief of symptoms, and 23% reported partial relief. All patients reported a substantial reduction in pain (75% &gt;5 points in visual analogue scale) and swelling (88% complete cessation). CONCLUSIONS Percutaneous sclerotherapy is a safe and effective treatment option of VM and secondary varicosis of the labia majora.