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ave a significant effect on the ANS in patients with LC, causing the predominance of the sympathetic branch activity over the parasympathetic one. Oxidative stress, triggering the relevant pathogenetic mechanisms has an effect on the autonomic nervous system in patients with liver cirrhosis. However, the realization of the dominant influence of the sympathetic branch of the autonomic nervous system is minimized due to the decrease in the sensitivity of receptors to vasoconstrictors, including to neurotransmitters.The article is devoted to the study of the diagnostic effectiveness of using magnifying chromoendoscopy when examining the oral cavity in patients with a gastroenterological profile with extra-esophageal manifestations of reflux disease. Pathologies of the oral cavity are often one of the additional symptoms, according to the Montreal Consensus and classification of gastroesophageal reflux disease (GERD). Barrett's esophagus is a serious complication of GERD, in which a cylindrical epithelium with intestinal metaplasia is found in the epithelial lining of the mucous membrane of the esophagus, which is a marker of this disease often in combination with dysplasia instead of squamous stratified non-keratinized epithelium. The relevance is due to the fact that this disease is considered as a precancerous condition and is associated with an increased risk of developing adenocarcinoma of the lower third of the esophagus. In this regard, timely diagnosis of Barrett's esophagus and monitoring of these patients will improve the prognosis of the disease and reduce the frequency of deaths.About 30-40% of multiple sclerosis (MS) patients treated with interferon-beta (IFN-ß) develop neutralizing antibodies (NABs) to IFN-ß. NABs reduce bioavailability of IFN-ß, which leads to a decrease in the therapy effectiveness. The introduction of IFN-ß induce production of several proteins, which are used as markers of the therapy effectiveness. In this study, we assessed the prognostic significance of MS activity biomarkers in relation to the clinical data of MS patients treated with IFN-ß. The study involved 30 MS patients receiving IFN-ß. The average duration of therapy was 3.5 (3.4-5.3) years. The study showed the prevalence of NAbs formation in MS patients was 13% of cases, a year later - 30%. The level of viperin in patients without exacerbations during the observation period was lower than in patients with exacerbations. The study revealed the prognostic significance of viperin in relation to the frequency of exacerbations viperin concentration above 0.2 ng / ml is a risk factor for exacerbation of MS. The results of this study suggest that viperin concentration in the serum could be used a prognostic marker in MS patients treated with interferons.While it is the most common inflammatory myopathy among middle-aged and elderly people, sporadic inclusion body myositis (IBM) presents as the most challenging disease to diagnose. The prevalence of IBM varies greatly depending on geographical, ethnic and age factors. Frequency of the disease incidence among the general population ranges from 11,000,000 to 114,000. Over the past 50 years, it has tripled. The etiology and pathogenetic mechanisms of IBM have not yet been fully studied and, therefore, the criteria for diagnosis and treatment have not been fully established. A treatment algorithm developed for other inflammatory myopathies is not effective in IBM. Thus, the aim of this work is to review, summarize and analyze the latest medical literature on etiopathogenesis, clinical phenotypes, global prevalence, genetic predisposition, diagnostic criteria and treatment trends for IBM, which will contribute to the improvement and practical application of current diagnostic and therapeutic methods of the disease.The article presents the results of a multicenter study of the etiology, antibiotic sensitivity and pharmacoepidemiology of infective endocarditis in the Russian Federation. The purpose of this study is to analyze the current practice of management of patients with infective endocarditis in conditions of low frequency of etiologically significant pathogens in the Russian Federation. The study included patients of both sexes of all age groups with definite and probable infective endocarditis. 406 cases of infectious endocarditis (240 in retrospect and 166 in the prospective part) were analyzed. Etiologically significant pathogen was isolated in 144 cases (35.5%). [https://www.selleckchem.com/products/ly3023414.html LY3023414] The structure of pathogens was dominated by gram (+) cocci (90.3%), most often - Staphylococcus aureus (46.5% of all isolated pathogens). Aminoglycosides (22.8%), parenteral cephalosporins of the III generation (22.1%) and glycopeptides (14.5%) were most frequently used in the course of starting antimicrobial therapy. When changing the mode of antimicrobial therapy, glycopeptides (18.6%), aminoglycosides (15.3%), fluoroquinolones (11.2%) and parenteral cephalosporins of generation III (9.5%) were most often prescribed.Family Mediterranean fever (FMF, Periodic disease) is a hereditary autosomal recessive disease and belongs to orphan diseases. Abdominal pain syndrome in this pathology is accompanied by various complaints from the gastrointestinal tract. The aim of the study was to study the state of the gastrointestinal tract in children with FMF. We observed 66 children aged 4 to 18 years with genetically confirmed FMF. The most frequent complaints were complaints of vomiting - 33.3% of cases and liquefied stools - 24.2% and nausea - 16.7% of cases. Erosive changes in the upper gastrointestinal tract were most often observed in the esophagus (up to 15.4%) during the attack and outside it. In endoscopic examination of the colon during the attack, changes in CO were significantly more common.Although the pathogenesis of periodontal lesions has not been sufficiently studied, recent studies show that plaque formation and host immune response are important factors. The purpose of this study was improving efficiency of plaque-induced gingivitis treatment in children with immunological correction of saliva by administration of polyvitamins and lysozyme tablets. We have examined 60 12-year-old children diagnosed with plaque-induced gingivitis and divided them into the main and control groups consisted of 30 children in each accordingly. The children of both groups were treated by sanitation and professional oral hygiene. The children of the main group besides were prescribed with multivitamins complex "Supervit" and tablets "Lizak". The efficiency of the introduced complex we have assessed by contain of immunoglobulins A (IgA), immunoglobulins G (IgG), secretory immunoglobulin A (s-IgA), interleukin 1β (IL-1β), interleukin 4 (IL-4) and lysozyme in saliva. After 6 month the treatment children from the main group showed a decline in concentration of IL-1β by 30,06 % (р less then 0,01), IgA by 33,34 %, IgG by 12,5 % (р less then 0,05).