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No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).Cavitation refers to the formation and collapse of vapor bubbles near solid boundaries in high-speed flows, such as ship propellers and pumps. During this process, cavitation bubbles focus fluid energy on the solid surface by forming high-speed jets, leading to damage and downtime of machinery. In response, numerous surface treatments to counteract this effect have been explored, including perfluorinated coatings and surface hardening, but they all succumb to cavitation erosion eventually. Here, we report on biomimetic gas-entrapping microtextured surfaces (GEMS) that robustly entrap air when immersed in water regardless of the wetting nature of the substrate. Crucially, the entrapment of air inside the cavities repels cavitation bubbles away from the surface, thereby preventing cavitation damage. We provide mechanistic insights by treating the system as a potential flow problem of a multi-bubble system. Our findings present a possible avenue for mitigating cavitation erosion through the application of inexpensive and environmentally friendly materials. [https://www.selleckchem.com/products/Rapamycin.html Rapamycin] Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).Frequency-stabilized optical frequency combs have created many high-precision applications. Accurate timing, ultralow phase noise, and narrow linewidth are prerequisites for achieving the ultimate performance of comb-based systems. Ultrastable cavity-based comb-noise stabilization methods have enabled sub-10-15-level frequency instability. However, these methods are complex and alignment sensitive, and their use has been mostly confined to advanced metrology laboratories. Here, we have established a simple, compact, alignment-free, and potentially low-cost all-fiber photonics-based stabilization method for generating multiple ultrastable combs. The achieved performance includes 1-femtosecond timing jitter, few times 10-15-level frequency instability, and less then 5-hertz linewidth, rivalling those of cavity-stabilized combs. This method features flexibility in configuration As a representative example, two combs were stabilized with 180-hertz repetition rate difference and ~1-hertz relative linewidth and could be used as an ultrastable, octave-spanning dual-comb spectroscopy source. The demonstrated method constitutes a mechanically robust and reconfigurable tool for generating multiple ultrastable combs suitable for field applications. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).High-entropy alloys exhibit exceptional mechanical properties at cryogenic temperatures, due to the activation of twinning in addition to dislocation slip. The coexistence of multiple deformation pathways raises an important question regarding how individual deformation mechanisms compete or synergize during plastic deformation. Using in situ neutron diffraction, we demonstrate the interaction of a rich variety of deformation mechanisms in high-entropy alloys at 15 K, which began with dislocation slip, followed by stacking faults and twinning, before transitioning to inhomogeneous deformation by serrations. Quantitative analysis showed that the cooperation of these different deformation mechanisms led to extreme work hardening. The low stacking fault energy plus the stable face-centered cubic structure at ultralow temperatures, enabled by the high-entropy alloying, played a pivotal role bridging dislocation slip and serration. Insights from the in situ experiments point to the role of entropy in the design of structural materials with superior properties. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).Topologically nontrivial spin textures such as vortices, skyrmions, and monopoles are promising candidates as information carriers for future quantum information science. Their controlled manipulation including creation and annihilation remains an important challenge toward practical applications and further exploration of their emergent phenomena. Here, we report controlled evolution of the helical and skyrmion phases in thin films of multiferroic Te-doped Cu2OSeO3 as a function of material thickness, dopant, temperature, and magnetic field using in situ Lorentz phase microscopy. We report two previously unknown phenomena in chiral spin textures in multiferroic Cu2OSeO3 anisotropic scaling and channeling with a fixed-Q state. The skyrmion channeling effectively suppresses the recently reported second skyrmion phase formation at low temperature. Our study provides a viable way toward controlled manipulation of skyrmion lattices, envisaging chirality-controlled skyrmion flow circuits and enabling precise measurement of emergent electromagnetic induction and topological Hall effects in skyrmion lattices. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).New discoveries in Glioblastoma (GBM) biology have been made using genomics data. Genomic markers are routinely integrated into clinical neurosurgical practice. In this manuscript, we review the fundamentals of genomics such as the differences between first, second, and third generation sequencing technology. We also review the impact of single cell genomics in understanding the complex heterogenous GBM microenvironment. Finally, we will discuss advances in epigenetics that have lent insights into treatment resistance. The integration of genomics into neuro-oncology clinical practice is routine and will continue to expand with the expansion of precision of medicine. We provide a primer for clinicians.