Zobrazení zdroje stránky Bauerfranklin2044

Here, we discuss how zebrafish is an important model for drug discovery, the process of how these discoveries emerge and future opportunities for maximizing zebrafish potential in medical discoveries.The retention phase has become an accepted part of orthodontic therapy. Irrespective of the patient's age, underlying malocclusion or the type of mechanotherapy, an orthodontist will use some retention method in virtually every patient following completion of the active treatment. This article presents a short description of the history of orthodontic retention and highlights major developments in retention strategy.In view of the diversity of orthodontic presentations, a single optimal retention protocol does not exist, with approaches tailored based on pre-treatment characteristics, treatment-induced changes and general patient characteristics. However, orthodontic practitioners should be responsive to the best available evidence to formulate optimal retention protocols in terms of appliance type, design and regimen, in particular. Based on a comprehensive search strategy, we discuss fundamental aspects concerning orthodontic retention of particular interest both to orthodontists and general dentists. These include stability and periodontal outcomes, cost-effectiveness, patient experiences, survival and failure rates of retainers, and the duration of retention.Patient adherence to removable retainer wear is integral to the long-term success of retention regimes. We discuss the factors influencing removable retainer wear, the methods of gauging wear levels, approaches to enhance adherence and the quality of online available information concerning retention. The potential value of patient involvement in approaches to retention within a shared decision-making framework and motivational interviewing are also highlighted.Orthodontic retention remains one of the great challenges in orthodontics. In this article, we discuss what is on the horizon to help address this challenge, including biological approaches to reduce relapse, treating patients without using retainers, technological developments, personalised medicine and the impact of COVID-19 on approaches to orthodontic retention.Introduction Long-term orthodontic retention using removable or fixed retainers is needed to maintain the outcome of orthodontic treatment. The aim of this article is to describe how long-term retention is managed and to report on a survey of general dental practitioners (GDPs) as to how this management currently operates in the UK.Materials and methods GDPs were invited to complete a short online survey on orthodontic retention using an open notice posted in the British Dental Journal and a direct email to the members of a local dental clinical society.Results Fifty-six GDPs completed the online survey. Overall, the findings highlighted poor levels of communication between orthodontists and GDPs with respect to the latter assuming responsibility for the management of long-term retention.Conclusion The management of long-term retention could be improved by more effective communication between the orthodontist and GDP. One solution might be a retention management pro forma. GDPs are in some instances willing to undertake more of the management of retention following further training and possible remuneration.Retaining teeth in their corrected positions following orthodontic treatment is one of the most challenging aspects of orthodontic practice. Despite much research, the rationale for retention is not entirely clear. Teeth tend to revert to their pre-treatment positions due to periodontal and gingival, soft tissue, occlusal and growth factors. Changes may also follow normal dentofacial ageing and are unpredictable with great variability. In this overview, each of these factors are discussed with their implications for retention, along with adjunctive procedures to minimise relapse. The state of current knowledge, methods used to assess relapse, factors regarded as predictive of or associated with stability as well as overcorrection are outlined. Potential areas requiring further investigation are suggested. The way in which the clinician may manage current retention practice, with a need for individualised retention plans and selective retainer wear, is also considered.Retention may be particularly challenging after the correction of specific malocclusion features, such as tooth rotations, open bite and expansion, which are all inherently unstable. In this article, some indications for active retention are reviewed by highlighting a variety of clinical techniques and appliances. Active retention is discussed in relation to preservation of tooth alignment and in the three planes of space sagittal, vertical and transverse. In some situations, an active retention regimen may be helpful to minimise or counteract relapse after orthodontic treatment and to improve patient satisfaction during the typically lengthy post-treatment period.This article provides an overview of removable orthodontic retainers, discussing their history and the different types available, and compares the two most popular removable retainers. Practical information on consent and the clinical steps involved in the provision of removable retainers, as well as suggested wear and care instructions, are also presented.Careful orthodontic treatment planning should involve the delineation of clear treatment objectives within each dental arch. Treatment planning decisions are underpinned by aesthetic goals, dental health considerations and the prospect of stability, with these factors often competing. There is also a near-universal acceptance of the requirement for some form of retention. A novel hierarchy of orthodontic stability is proposed. As further evidence emerges and technical refinement continues, it is likely that this will undergo further adaptation. Ultimately, however, this knowledge will ensure that our understanding of the merits of orthodontic intervention, allied to the burden of retention, can be clearly presented to prospective orthodontic patients.Bonded retainers may play an important role in reducing unwanted tooth movements following orthodontic treatment, with an open-ended perspective on retention now established. [https://www.selleckchem.com/products/AP24534.html click here] The importance of planning for bonded retention is emphasised, with key principles in minimising failure rates as well as wire and adhesive options discussed. Approaches to preparation of the wire and the teeth, the bonding process, as well as variations in retainer design, and means of preventing problems and undertaking repairs in order to achieve predictable fixed retention in the long term are also outlined.