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The search for organic molecules at the surface of Mars is a key objective in astrobiology, given that many organic compounds are possible biosignatures and their presence is of interest with regard to the habitability of Mars. Current environmental conditions at the martian surface are harsh and affect the stability of organic molecules. For this reason, and because current and future Mars rovers collect samples from the upper surface layer, it is important to assess the fate of organic molecules under the conditions at the martian surface. Here, we present an experimental study of the evolution of uracil when exposed to UV radiation, pressure, and temperature conditions representative of the surface of Mars. Uracil was selected because it is a nucleobase that composes RNA, and it has been detected in interplanetary bodies that could be the exogenous source of this molecule by meteoritic delivery to the surface of Mars. Our results show that the experimental quantum efficiency of photodecomposition of uracil is 0.16 ± 0.14 molecule/photon. Although these results suggest that uracil is quickly photodegraded when directly exposed to UV light on Mars, such exposure produces dimers that are more stable over time than the monomer. The identified dimers could be targets of interest for current and future Mars space missions.Terrestrial simulations for crewed missions are critically important for testing technologies and improving methods and procedures for future robotic and human planetary exploration. In February 2018, AMADEE-18 simulated a mission to Mars in the Dhofar region of Oman. During the mission, a field crew coordinated by the Österreichisches Weltraum Forum (OeWF) accomplished several experiments in the fields of astrobiology, space physiology and medicine, geology, and geophysics. Within the scientific payload of AMADEE-18, ScanMars provided geophysical radar imaging of the subsurface at the simulated landing site and was operated by analog astronauts wearing spacesuits during extra-vehicular activities. The analog astronauts were trained to operate a ground-penetrating radar instrument that transmits and then collects radio waves carrying information about the geological setting of the first few meters of the subsurface. The data presented in this work show signal returns from structures down to 4 m depth, associaely 2000 m of radar data profiles have been acquired during the analog mission. Combining the results for ScanMars, orbital remote sensing data, and first-person observation in the field while wearing spacesuits (analog astronauts), it was possible to generate a geological model at the AMADEE-18 study site.Between February 1 and 28, 2018, the Austrian Space Forum, in cooperation with the Oman Astronomical Society and research teams from 25 nations, conducted the AMADEE-18 mission, a human-robotic Mars expedition simulation in the Dhofar region in the Sultanate of Oman. As a part of the AMADEE-18 simulated Mars human exploration mission, the Remote Science Support team performed analyses of the Dhofar area (Oman) in an effort to characterize the region as a potential Mars analog site. The main motivation of this research was to study and register selected samples collected by analog astronauts during the AMADEE-18 mission with laboratory analytical methods and techniques comparable with those that are likely to be used on Mars in the future. The 25 samples representing unconsolidated sediments obtained during the simulated mission were studied by using optical microscopy, Raman spectroscopy, X-ray diffraction, laser-induced breakdown spectroscopy, and laser-induced fluorescence spectroscopy. The principal results show the existence of minerals and alteration processes related to volcanism, hydrothermalism, and weathering. The analogy between the Dhofar region and the Eridana Basin region of Mars is clearly noticeable, particularly as an analog for secondary minerals formed in a hydrothermal seafloor volcanic-sedimentary environment. The synergy between the techniques used in the present work provides a solid basis for the geochemical analyses and organic detection in the context of future human-robotic Mars expeditions. AMADEE-18 has been a prime test bed for geoscientific workflows with astrobiological relevance and has provided valuable insights for future space missions.<br /><br /> On March 23, 2018 a Tesla Model X driver was killed in Mountain View, CA after colliding with a previously collapsed crash attenuator at a speed of 31.7 m/s (70.8 mph). The attenuator, which must be repaired following a collision, had been struck 11 days prior by a 2010 Toyota Prius at a minimum speed of 33.9 m/s (75.8 mph). The Toyota driver survived. The maintenance of traffic safety hardware and benefit of the crash attenuator are evaluated.<br /><br /> Public information from an NTSB investigation is used to evaluate crash impact severity. Vehicle crash data from Event Data Recorders (EDRs) are compared with test data for the SCI Smart Cushion 100GM crash attenuator. An idealized triangular crash pulse is used to estimate longitudinal peak impact acceleration, and longitudinal impact energy is calculated. The medical outcomes for drivers are considered.<br /><br /> The California Department of Transportation (Caltrans) maintenance and repair program for safety critical traffic safety hardware was found to be ineffective. [https://www.selleckchem.com/products/sgc-cbp30.html Selleck SGC-CBP30] The Tesla collision into the nonfunctional attenuator was estimated have roughly three times the impact force to the passenger compartment as it would have been if striking a functional attenuator.<br /><br /> The Tesla driver could have survived the collision had the crash attenuator been functional. Roadway management and timely maintenance of safety critical traffic hardware are necessary to ensure safety.<br /><br />The Tesla driver could have survived the collision had the crash attenuator been functional. Roadway management and timely maintenance of safety critical traffic hardware are necessary to ensure safety.The focus of this review is the human de novo purine biosynthetic pathway. The pathway enzymes are enumerated, as well as the reactions they catalyze and their physical properties. Early literature evidence suggested that they might assemble into a multi-enzyme complex called a metabolon. The finding that fluorescently-tagged chimeras of the pathway enzymes form discrete puncta, now called purinosomes, is further elaborated in this review to include a discussion of their assembly; the role of ancillary proteins; their locus at the microtubule/mitochondria interface; the elucidation that at endogenous levels, purinosomes function to channel intermediates from phosphoribosyl pyrophosphate to AMP and GMP; and the evidence for the purinosomes to exist as a protein condensate. The review concludes with a consideration of probable signaling pathways that might promote the assembly and disassembly of the purinosome, in particular the identification of candidate kinases given the extensive phosphorylation of the enzymes.