Zobrazení zdroje stránky Alvarezmcneil1141

Before they even speak, infants become attuned to the sounds of the language(s) they hear, processing native phonetic contrasts more easily than nonnative ones. For example, between 6 to 8 mo and 10 to 12 mo, infants learning American English get better at distinguishing English and [l], as in "rock" vs. [https://www.selleckchem.com/CDK.html selleck chemical] "lock," relative to infants learning Japanese. Influential accounts of this early phonetic learning phenomenon initially proposed that infants group sounds into native vowel- and consonant-like phonetic categories-like and [l] in English-through a statistical clustering mechanism dubbed "distributional learning." The feasibility of this mechanism for learning phonetic categories has been challenged, however. Here, we demonstrate that a distributional learning algorithm operating on naturalistic speech can predict early phonetic learning, as observed in Japanese and American English infants, suggesting that infants might learn through distributional learning after all. We further show, however, that, contrary to the original distributional learning proposal, our model learns units too brief and too fine-grained acoustically to correspond to phonetic categories. This challenges the influential idea that what infants learn are phonetic categories. More broadly, our work introduces a mechanism-driven approach to the study of early phonetic learning, together with a quantitative modeling framework that can handle realistic input. This allows accounts of early phonetic learning to be linked to concrete, systematic predictions regarding infants' attunement.<br /><br /> The ubiquitin-proteasome system (UPS) and the autophagy-lysosomal system (APLS) are major intracellular degradation procedures. The importance of the APLS in podocytes is established, but the role of the UPS is not well understood.<br /><br /> To investigate the role of the UPS in podocytes, mice were generated that had deletion of <br /><br /> (<br /><br /> <br /><br /> ), which encodes an essential regulatory subunit required for construction of the 26S proteasome and its deubiquitinating function.<br /><br /> <br /><br /> mice showed albuminuria and glomerulosclerosis, leading to CKD. Impairment of proteasome function caused accumulation of ubiquitinated proteins and of oxidative modified proteins, and it induced podocyte apoptosis. Although impairment of proteasome function normally induces autophagic activity, the number of autophagosomes was lower in podocytes of <br /><br /> 3<br /><br /> mice than in control mice, suggesting the autophagic activity was suppressed in podocytes with impairment of proteasome function. In an <br /><br /> study, antioxidant apocynin and autophagy activator rapamycin suppressed podocyte apoptosis induced by proteasome inhibition. Moreover, rapamycin ameliorated the glomerular injury in the <br /><br /> <br /><br /> mice. The accumulation of ubiquitinated proteins and of oxidative modified proteins, which were detected in the podocytes of <br /><br /> <br /><br /> mice, is a characteristic feature of aging. An aging marker was increased in the podocytes of <br /><br /> <br /><br /> mice, suggesting that impairment of proteasome function promoted signs of aging in podocytes.<br /><br /> Impairment of proteasome function in podocytes led to CKD, and antioxidants and autophagy activators can be therapeutic agents for age-dependent CKD.<br /><br />Impairment of proteasome function in podocytes led to CKD, and antioxidants and autophagy activators can be therapeutic agents for age-dependent CKD.<br /><br /> CKD is associated with sudden cardiac death and atrial fibrillation (AF). However, other types of arrhythmia and different measures of the burden of arrhythmias, such as presence and frequency, have not been well characterized in CKD.<br /><br /> To quantify the burden of arrhythmias across CKD severity in 2257 community-dwelling adults aged 71-94 years, we examined associations of major arrhythmias with CKD measures (eGFR and albuminuria) among individuals in the Atherosclerosis Risk in Communities study. Participants underwent 2 weeks of noninvasive, single-lead electrocardiogram monitoring. We examined types of arrhythmia burden presence and frequency of arrhythmias and percent time in arrhythmias.<br /><br /> Of major arrhythmias, there was a higher prevalence of AF and nonsustained ventricular tachycardia among those with more severe CKD, followed by long pause (&gt;30 seconds) and atrioventricular block. Nonsustained ventricular tachycardia was the most frequent major arrhythmia (with 4.2 episodes per person-month). MostAF and nonsustained ventricular tachycardia. Additionally, eGFR is associated with less frequent atrioventricular block, whereas albuminuria is associated with more frequent ventricular ectopy. Use of a novel, 2-week monitoring approach demonstrated a broader range of arrhythmias associated with CKD than previously reported.<br /><br /> Early motor impairments have been reported in children with neurodevelopmental disorders (NDD), but it is not clear if early detection of motor impairments can identify children at risk for NDD or how early such impairments might be detected.<br /><br /> To characterize early motor function in children later diagnosed with NDD relative to typically developing children or normative data.<br /><br /> The Cumulative Index to Nursing and Allied Health Literature, Embase, Medline, PsycINFO, and Scopus electronic databases were searched.<br /><br /> Eligible studies were required to include an examination of motor function in children (0-24 months) with later diagnosis of NDD by using standardized assessment tools.<br /><br /> Data were extracted by 4 independent researchers. The quality of the studies was assessed by using the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields checklist.<br /><br /> Twenty-five studies were included in this review; in most of the studies, the authors examined children with later autism spectrum disorder (ASD). Early motor impairments were detected in children later diagnosed with ASD. The meta-analysis results indicated that differences in fine, gross, and generalized motor functions between the later ASD and typically developing groups increased with age. Motor function across different NDD groups was found to be mixed.<br /><br /> Results may not be applicable to children with different types of NDD not reported in this review.<br /><br /> Early motor impairments are evident in children later diagnosed with ASD. More research is needed to ascertain the clinical utility of motor impairment detection as an early transdiagnostic marker of NDD risk.<br /><br />Early motor impairments are evident in children later diagnosed with ASD. More research is needed to ascertain the clinical utility of motor impairment detection as an early transdiagnostic marker of NDD risk.