Zobrazení zdroje stránky Aguilarjordan1813

Socioneuroscience studies the relations between the human brain and social interactions taking into account knowledge from all social sciences and the natural sciences. Processes of conscious versus unconscious social volition and control is one central area of inquiry in socioneuroscience. In this article, we discuss the dominant coercive discourse in society -which presents males with aggressive attitudes and behaviors as more attractive- as an example of social control of human volition which imprisons many individuals' sexual freedom. However, due to brain plasticity, certain experiences that question such dominant discourse and empty violence from attractiveness open up the possibility for the individual and the society to break free from the neural wiring imposed by the dominant coercive discourse and, in the words of Santiago Ramón y Cajal, be ourselves "the architects of our brain", contributing to overcome violence against women. © 2019 the Author(s), licensee AIMS Press.In recent decades, consumption of psychostimulants has been significantly increased all over the world, while exact mechanisms of neurochemical effects of psychomotor stimulants remained unclear. It is assumed that the neuronal messenger nitric oxide (NO) may be involved in mechanisms of neurotoxicity evoked by psychomotor stimulants. However, possible participation of NO in various pathological states is supported mainly by indirect evidence because of its short half-life in tissues. Aim of this review is to describe the involvement of NO and the contribution of lipid peroxidation (LPO) and acetylcholine (ACH) release in neurotoxic effects of psychostimulant drugs. NO was directly determined in brain structures by electron paramagnetic resonance (EPR). Both NO generation and LPO products as well as release of ACH were increased in brain structures following four injections of amphetamine (AMPH). Pretreatment of rats with the non-selective inhibitor of NO-synthase (NOS) N-nitro-L-arginine or the neuronal NOS inhibitor 7-nitroindazole significantly reduced increase of NO generation as well as the rise of ACH release induced by AMPH. Both NOS inhibitors injected prior to AMPH had no effect on enhanced levels of LPO products. Administration of the noncompetitive NMDA receptor antagonist dizocilpine abolished increase of both NO content and concentration of LPO products induced by of the psychostimulant drug. Dizocilpine also eliminated the influence of AMPH on the ACH release. Moreover, the neurochemical and neurotoxic effects of the psychostimulant drug sydnocarb were compared with those of AMPH. Single injection of AMPH showed a more pronounced increase in NO and TBARS levels than after an equimolar concentration of sydnocarb. The findings demonstrate the crucial role of NO in the development of neurotoxicity elicited by psychostimulants and underline the key role of NOS in AMPH-induced neurotoxicity. © 2019 the Author(s), licensee AIMS Press.Eight (8) computer science students, novice programmers, who were in the first semester of their studies, participated in a field study in order to explore potential differences in their brain activity during programming with a visual programming language versus a textual programming language. The eight students were asked to develop two specific programs in both programming languages (a total of four tasks). The order of these programs was determined, while the order of languages in which they worked differed between the students. Measurement of cerebral activity was performed by the electroencephalography (EEG) imaging method. According to the analysis of the data it appears that the type of programming language did not affect the students' brain activity. Also, six students needed more time to successfully develop the programs they were asked with the first programming language versus the second one, regardless of the type of programming language that was first. In addition, it appears that six students did not show reducing or increasing brain activity as they spent their time on tasks and at the same time did not show a reduction or increase in the time they needed to develop the programs. Finally, the students showed higher average brain activity in the development of the fourth task than the third, and six of them showed higher average brain activity when developing the first versus the second program, regardless of the programming language. The results can contribute to a) highlighting the need for a diverse educational approach for students when engaging in program development and b) identifying appropriate learning paths to enhance student education in programming. [https://www.selleckchem.com/products/peg300.html PEG300 in vitro] © 2019 the Author(s), licensee AIMS Press.Ever since the late-eighties when endothelium-derived relaxing factor was found to be the gas nitric oxide, endogenous nitric oxide production has been observed in virtually all animal groups tested and additionally in plants, diatoms, slime molds and bacteria. The fact that this new messenger was actually a gas and therefore didn't obey the established rules of neurotransmission made it even more intriguing. In just 30 years there is now too much information for useful comprehensive reviews even if limited to animals alone. Therefore this review attempts to survey the actions of nitric oxide on development and neuronal function in selected major invertebrate models only so allowing some detailed discussion but still covering most of the primary references. Invertebrate model systems have some very useful advantages over more expensive and demanding animal models such as large, easily identifiable neurons and simple circuits in tissues that are typically far easier to keep viable. A table summarizing this information along with the major relevant references has been included for convenience. © 2019 the Author(s), licensee AIMS Press.The aim of present study is to investigate pretreatment with hydroalcoholic extract of Alpinia officinarum rhizome on the severity of epilepsy and memory impairment in rat. In this experimental study, rats were randomly assigned to seven groups. Control group and negative control group were intraperitoneally injected with normal saline and PTZ, respectively, for 10 days. The intervention groups received A. officinarum extract at different doses (50, 100 and 150 mg/kg) 30 minutes before PTZ injection. A. officinarum extract treatment in rats with PTZ-induced kindling exerted significant increase in seizure latency and significant decrease in the frequency of total body seizure, frequent spinning, and jumping. Flumazenil significantly inhibited the antiepileptic effects of A. officinarum extract in the rat receiving the extract at 150 mg/kg. A. officinarum extract can inhibit PTZ-induced seizure and memory impairment, and therefore can be considered as a potent agent which warranted further research to clarify its effects.