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straints of LMIC health systems and will add to our understanding of factors shaping clinical practice among primary care providers. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) DERR1-10.2196/15569. ©Rob Stephenson, Nicholas Metheny, Tamar Goldenberg, Nataliia Bakunina, Sofia De Vasconcelos, Karel Blondeel, James Kiarie, Igor Toskin. Originally published in JMIR Research Protocols (http//www.researchprotocols.org), 10.03.2020.BACKGROUND When searching for health information, many people use the internet as their first source of information. In online health forums, for example, users post their questions and exchange health advice. In recent years, information givers from various professions have begun to use positive language (indicated by the frequent use of positively valenced adjectives) to communicate their information and persuade their audiences. OBJECTIVE The goal of the current study was to answer the following research questions (1) How does positive language, in comparison to neutral language, influence the trustworthiness of a person arguing in an online health forum and the credibility of their health claims; (2) How does working for a university, compared to working for a lobbying organization, influence the trustworthiness of a person arguing in an online health forum and the credibility of their health claims; and (3) Do the two factors of language style and professional affiliation interact with each other to inflhors are trustworthy and their information is credible. ©Lars König, Regina Jucks. Originally published in the Journal of Medical Internet Research (http//www.jmir.org), 10.03.2020.BACKGROUND Couples struggling with infertility are increasingly turning to the internet for infertility-related content and to connect with others. Most of the published data on infertility and the internet only address the experiences of women, with limited studies focusing exclusively on internet discussions on male factor infertility. OBJECTIVE The aim of this study was to understand the concerns and experiences of discussants on an online male infertility community and to provide insight into their perceptions of interactions with health care professionals. METHODS Using the large-scale data analytics tool BigQuery, we extracted all posts in the r/MaleInfertility community (877 members) of the social media website and discussion board Reddit from November 2017 to October 2018. We performed a qualitative thematic analysis and quantitative semantic analysis using Language Inquiry and Word Count 2015 of the extracted posts to identify dominant themes and subthemes of discussions. Descriptive statistics and sprove in-office patient education. ©Vadim Osadchiy, Jesse Nelson Mills, Sriram Venkata Eleswarapu. Originally published in the Journal of Medical Internet Research (http//www.jmir.org), 10.03.2020.BACKGROUND Generation Z is starting to reach college age. They have adopted technology from an early age and have a deep dependence on it; therefore, they have become more drawn to the virtual world. M-learning has experienced huge growth in recent years, both in the medical context and in medical and health sciences education. Ultrasound imaging is an important diagnosis technique in physiotherapy, especially in sports pathology. M-learning systems could be useful tools for improving the comprehension of ultrasound concepts and the acquisition of professional competencies. OBJECTIVE The purpose of this study was to evaluate the efficacy and use of an interactive platform accessible through mobile devices-Ecofisio-using ultrasound imaging for the development of professional competencies in the evaluation and diagnosis of sports pathologies. METHODS Participants included 110 undergraduate students who were placed into one of two groups of a randomized controlled multicenter study control group (ie, traditional-Castillo, Carolina Fernández-Lao, Paula Postigo-Martin, Francisco Álvarez-Salvago, Manuel Arroyo-Morales, Irene Cantarero-Villanueva. Originally published in the Journal of Medical Internet Research (http//www.jmir.org), 10.03.2020.The distribution of complementary metabolic functions in hepatocytes along a portocentral axis is called liver zonation. Endothelial secreted Wnt ligands maintain metabolic zonation in the adult murine liver but whether those ligands are necessary to initiate zonation in the immature liver has been only partially explored. Also, numerous non-metabolic proteins display zonated expression in the adult liver but it is not entirely clear if their localization requires endothelial Wnts. Here we used a novel transgenic mouse model to compare the spatial distribution of zonated non-metabolic proteins with that of typical zonated metabolic enzymes during liver maturation and after acute injury induced by carbon tetrachloride (CCl4). We also investigated how preventing Wnt ligand secretion from endothelial cells affects zonation patterns under homeostasis and after acute injury. [https://www.selleckchem.com/products/sulfopin.html Sulfopin nmr] Our study demonstrates that metabolic and non-metabolic zonation are established non-synchronously during maturation and regeneration and require multiple endothelial Wnt sources. © 2020, Ma et al.The process by which visual information is incorporated into the brain's spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling the virtual environment from mouse behavior degraded spatial representations and provided evidence that supralinear integration of visual and motor inputs contributes to landmark encoding. V1 axons recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tuning. Our data indicate that landmark representations in RSC are the result of local integration of visual, motor, and spatial information.